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Literature searching

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To find the best available evidence you need to:

  • Translate a knowledge gap into a well built clinical/research question 
  • Establish what type of question you have 
  • Choose which type of study will best answer your question

PICO and alternatives

Developing a well-built question takes a bit of practice. The PICO mnemonic can be used to help develop or frame your question and is typically used for intervention or treatment type questions.

The type of question you ask will dictate the framework to use, so if your question doesn't fit the PICO format, consider using an alternative. 

For an explanation of PICO and its use in evidence based practice: How to clarify a clinical question.

CoCoPop recommended for Prevalence or Incidence

Condition, Context, Population

Ref:

Munn, Z., Moola, S., Lisy, K., Riitano, D., & Tufanaru, C. (2015). Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data. International Journal of Evidence-Based Healthcare13(3), 147–153. https://doi.org/10.1097/XEB.0000000000000054

PCC recommended for Scoping Reviews

Population or Participants, Concept, Context

Ref:

Peters, M. D. J., Marnie, C., Tricco, A. C., Pollock, D., Munn, Z., Alexander, L., McInerney, P., Godfrey, C. M., & Khalil, H. (2020). Updated methodological guidance for the conduct of scoping reviews. JBI Evidence Synthesis, 18(10), 2119–2126. https://doi.org/10.11124/JBIES-20-00167

PEO recommended for Etiology or Risk

Population, Exposure, Outcome(s)

PECO C = Comparison

Ref: 

Moola, S., Munn, Z., Sears, K., Sfetcu, R., Currie, M., Lisy, K., Tufanaru, C., Qureshi, R., Mattis, P., & Mu, P. (2015). Conducting systematic reviews of association (etiology): The Joanna Briggs Institute's approach. International Journal of Evidence-Based Healthcare13(3), 163–169. https://doi.org/10.1097/XEB.0000000000000064

PICO recommended for Intervention/Treatment effectiveness

Population/Patient/Problem, Intervention, Comparison, Outcome

PICO variations/extensions:

PICOC = Context/setting, PICOR = Research design, PICOS = Study type, PICOT = Timeframe,

Ref:

Anderson, P. F., & Booth, A. (2022). Question frameworks. In M. J. Foster & S. T.  Jewell (Eds.), Piecing together systematic reviews and other evidence syntheses (pp. 45-56). Rowman & Littlefield.

PIRD recommended for Diagnostic Test Accuracy

Population, Index test, Reference test, Diagnosis of Interest

Ref: 

Campbell, J. M., Klugar, M., Ding, S., Carmody, D. P., Hakonsen, S. J., Jadotte, Y. T., White, S., & Munn, Z. (2015). Diagnostic test accuracy: methods for systematic review and meta-analysis. International Journal of Evidence-Based Healthcare13(3), 154–162. https://doi.org/10.1097/XEB.0000000000000061

PCC recommended for Scoping Reviews

Population or Participants, Concept, Context

Ref:

Peters, M. D. J., Marnie, C., Tricco, A. C., Pollock, D., Munn, Z., Alexander, L., McInerney, P., Godfrey, C. M., & Khalil, H. (2020). Updated methodological guidance for the conduct of scoping reviews. JBI Evidence Synthesis, 18(10), 2119–2126. https://doi.org/10.11124/JBIES-20-00167

PEO

Population, Exposure of Interest, Outcome or Response

Ref:

Moola, S., Munn, Z., Sears, K., Sfetcu, R., Currie, M., Lisy, K., Tufanaru, C., Qureshi, R., Mattis, P., & Mu, P. (2015). Conducting systematic reviews of association (etiology): The Joanna Briggs Institute's approach. International Journal of Evidence-Based Healthcare13(3), 163–169. https://doi.org/10.1097/XEB.0000000000000064

PICo

Population, Interest, Context

Ref:

Lockwood, C., Munn, Z., & Porritt, K. (2015). Qualitative research synthesis: methodological guidance for systematic reviewers utilizing meta-aggregation. International Journal of Evidence-Based Healthcare13(3), 179–187. https://doi.org/10.1097/XEB.0000000000000062

SPICE

Setting, Perspective, Intervention, Comparison, Evaluation

Ref: 

Booth, A. (2004). Formulating answerable questions. In A. Booth & A. Brice (Eds.), Evidence based practice for information professionals: A handbook. (pp. 61-70). Facet.

SPIDER

Sample, Phenomenon of Interest, Design, Evaluation, Research Type

Ref:

Cooke, A., Smith, D., & Booth, A. (2012). Beyond PICO: the SPIDER tool for qualitative evidence synthesis. Qualitative Health Research22(10), 1435–1443. https://doi.org/10.1177/1049732312452938

CLIP or ECLIPSe recommended for health policy/management

CLIP: Client Group, Location, Improvement or Information or Innovation, Professionals

ECLIPSe: Expectation, Client Group, Location, Impact, Professionals, Service

Ref: 

Wildridge, V., & Bell, L. (2002). How CLIP became ECLIPSE: A mnemonic to assist in searching for health policy/management information. Health Information & Libraries Journal, 19(2): 113-115. https://doi.org/10.1046/j.1471-1842.2002.00378

There are many more frameworks available, explore the following articles to find out more:

Booth, A., Noyes, J., Flemming, K., Moore, G., Tunçalp, Ö., & Shakibazadeh, E. (2019). Formulating questions to explore complex interventions within qualitative evidence synthesis. BMJ Global Health, 4(Suppl 1), e001107. https://doi.org/10.1136/bmjgh-2018-001107

Munn, Z., Stern, C., Aromataris, E., Lockwood, C., & Jordan, Z. (2018). What kind of systematic review should I conduct? A proposed typology and guidance for systematic reviewers in the medical and health sciences. BMC Medical Research Methodology, 18(1), 1–9. https://doi.org/10.1186/s12874-017-0468-4